Provera is the brand name for medroxyprogesterone, a synthetic form of the hormone progesterone. People use it for several gynecologic issues: to control heavy or irregular bleeding, to induce a period after missed cycles, and as part of hormone replacement therapy to protect the uterine lining when estrogen is given.
You might also hear about Depo-Provera. That’s an injectable form of medroxyprogesterone used for contraception. Even though they share the same active drug, the pill and the shot work differently in terms of dose, schedule, and side effects.
Doctors prescribe Provera for short courses or as ongoing therapy depending on the reason. Short courses are often used to trigger a withdrawal bleed after missed periods. Longer courses can help manage ongoing irregular bleeding or protect the endometrium during estrogen therapy. Because individual needs vary, follow your prescriber's plan and ask about the goal of treatment before you start.
If you’re switching from the pill to a shot or considering an IUD instead, ask about how each option affects fertility, bleeding patterns, and side effects. Those differences matter when picking the right option for you.
Common side effects include spotting or irregular bleeding, mood swings, breast tenderness, bloating, and mild headaches. Some people notice weight changes. With long-term use, monitoring is sensible—your doctor may check blood pressure, ask about mental health changes, and schedule routine breast and pelvic exams.
There are some situations where Provera isn’t a good choice: current or past breast cancer, unexplained vaginal bleeding that hasn’t been evaluated, active blood clots, or known pregnancy. Tell your provider about smoking, migraines with aura, liver problems, or any family history of clotting—these can change the safety balance.
Drug interactions exist. Always tell your prescriber about other medicines, herbal supplements, or strong antibiotics and seizure drugs you take. These can change how well Provera works or increase side effects.
Want alternatives? For some people natural progesterone, a levonorgestrel IUD, or other hormonal options may be better. The best choice depends on your health history, whether you want contraception, and how you feel about side effects.
Bottom line: Provera is a common and useful medication for several menstrual and hormonal issues, but it’s not one-size-fits-all. Ask clear questions—why this drug, how long, what to expect—and check in with your provider if side effects or new symptoms appear. If you want, look for articles here about hormone options and safe ways to compare treatments before you decide.
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