Ketorolac tromethamine (usually just called ketorolac) is a strong nonsteroidal anti-inflammatory drug (NSAID) used for short-term relief of moderate to severe pain. It’s not for everyday aches — think post-op pain, kidney stone pain, or other acute pain where opioid-sparing relief is needed. It works by blocking the chemicals that cause pain and inflammation.
Ketorolac comes as an injection (IV or IM), and as oral tablets. Dosing varies, but some common rules apply: keep total treatment short. Adults usually get an initial IV/IM dose (often 30 mg) then smaller doses every 6 hours, or 10 mg by mouth every 4–6 hours. The key rule: don’t use ketorolac for more than 5 days in a row — that includes any combination of injections and tablets.
If you are older than 65, weigh less than 50 kg (110 lb), or have reduced kidney function, doctors usually lower the dose. Always follow the exact prescription you get from your provider. Never mix ketorolac with other NSAIDs (ibuprofen, naproxen) — that raises the risk of bleeding and kidney problems.
Short-term use still carries risks. The most common side effects are stomach pain, heartburn, nausea, dizziness, and headache. More serious problems include gastrointestinal bleeding, ulcers, kidney injury, and increased bleeding risk — especially if you’re on blood thinners (warfarin, DOACs) or have a peptic ulcer history.
Do not use ketorolac if you have active bleeding, recent stomach ulcer, advanced kidney disease, or if you’re in the third trimester of pregnancy. Avoid if you recently had major surgery with a high bleeding risk. Tell your provider about all medicines you take — especially anticoagulants, other NSAIDs, and certain blood pressure drugs — and about any allergy to aspirin or NSAIDs.
When should you call the doctor? Seek help for black or bloody stools, vomiting blood, severe stomach pain, little or no urine, sudden shortness of breath, chest pain, or signs of an allergic reaction (rash, swelling, difficulty breathing).
Storage and practical tips: keep tablets at room temperature away from moisture. If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose; don’t double up. If you’re prescribed ketorolac after surgery, ask the surgeon and anesthesiologist about bleeding risk before taking it.
Ketorolac can be useful for strong, short-term pain, but it’s not a long-term pain solution. If pain persists after the 5-day limit, talk to your provider about safer alternatives or further evaluation. Prefer a quick answer? Ask your pharmacist or clinician whether ketorolac is right for your situation before taking it.
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