Dolutegravir Side Effects: What You Need to Know Before Taking It

When you’re taking dolutegravir, a once-daily HIV medication that stops the virus from multiplying. Also known as DTG, it’s a key part of many HIV treatment plans because it works fast and stays in your system well. But like all drugs, it’s not without risks. While most people tolerate it fine, some face side effects that can be serious—especially if you don’t know what to look for.

One of the biggest concerns with dolutegravir, a type of integrase inhibitor used in antiretroviral therapy is weight gain. Studies show people on dolutegravir tend to gain more weight than those on older HIV drugs, especially if they’re also taking tenofovir alafenamide. It’s not just a little extra pounds—some gain 10% or more of their body weight in a year. That’s not just cosmetic; it can raise your risk for diabetes and heart problems. Then there’s the rare but real chance of neural tube defects in babies if taken early in pregnancy. That’s why doctors screen for pregnancy before starting this drug and often switch women to other options if they’re planning to conceive.

Other common side effects include headaches, trouble sleeping, and mild nausea—things you might brush off as stress or bad luck. But if you start feeling unusually tired, develop a rash that won’t go away, or notice yellowing in your eyes or skin, those aren’t normal. They could mean your liver is struggling. Dolutegravir can affect liver function, especially if you already have hepatitis B or C. And while depression or anxiety isn’t listed as a top side effect, many patients report mood changes that improve after switching meds. It’s not in every trial, but it’s common enough in real life to pay attention to.

You’re not alone if you’re worried. Thousands of people take dolutegravir safely every day. But knowing what to watch for makes all the difference. The goal isn’t to scare you—it’s to help you spot problems early so you can talk to your doctor before things get worse. That’s why we’ve gathered real patient experiences, clinical notes, and doctor advice into this collection. You’ll find comparisons with other HIV drugs, tips for managing side effects at home, and what to do if you think your symptoms are more than just a bad day.